In 2002, as part of our national community mobilization work, we recognized that the growing Latino communities in the South frequently had no access to healthcare, were not being adequately reached through traditional health/ prevention awareness programs, and faced numerous language barriers as many health service agencies lacked Spanish-speaking or culturally conversant employees. In 2006 we met with the Ford Foundation to discuss the urgent need to support our vision to develop a regional Latino initiative in the southern region of the United States. In the summer of 2007, the Latino Commission on AIDS launched its strategic program initiative: Latinos in the Deep South. Latinos in the Deep South worked in seven states: North Carolina, South Carolina, Alabama, Georgia, Tennessee, Louisiana and Mississippi.
Since 2012, the Latinos in the Deep South program has been housed in North Carolina. In 2019, Latinos in the Deep South becomes Latinos in the South adding Texas and Florida to target states. That same year, Latinos in the South convened it's first Encuentro, a yearly, Southern gathering of multi-racial Latinx LGBTQ community and allies to end the HIV epidemic.